Precision Clinical AI
Zero Mathematical Hallucination
MedOrqis equips Frontier AI models (Claude 3.5, Gemini 1.5, OpenAI) with 24 structured clinical skills and pure deterministic mathematical engines. Clinical calculators never delegate arithmetic to probabilistic weights.
Why Clinical AI Requires Zero-Token Math
LLMs excel at synthesizing complex patient histories and clinical literature, but fail at exact medical arithmetic. MedOrqis establishes a non-negotiable architectural boundary.
Unassisted Frontier LLMs
Generative Token Prediction- Fractional Exponent Drift: Models hallucinate decimal values in CKD-EPI (2021) and Cockcroft-Gault formulas, risking nephrotoxic dosing.
- Guideline Conflation: Mixing obsolete female point adjustments into ESC 2024 CHA2DS2-VA calculations.
- Plausible Hallucination on Missing Data: Guessing baseline creatinine or patient weight when unspecified, rather than halting safely.
Frontier LLM + MedOrqis Skills
Deterministic Hybrid Execution- Pure Mathematical Engines: Calculations run in zero-token native code. 100% mathematical reproducibility across runs.
- Strict Guideline Version Tagging: ESC 2024 vs ACC/AHA 2023 algorithms are partitioned into distinct, auditable tools.
- Deterministic SafeCalculationRefusal: Throws structured clinical exceptions with remediation guidance if required parameters are missing.
7 Clinical Specialization Clusters
Derived from official MedOrqis v2.1.1 repository manifests.
Emergency Triage & Clinical Safety Gates
High-urgency primary surveys, life-threatening symptom escalation, toxic ingestions, and pre-output safety audits.
Pharmacology, Polypharmacy & Renal Dosing
Deterministic Cockcroft-Gault / eGFR renal dose adjustments, 2023 AGS Beers Criteria deprescribing, and drug-drug interaction defense.
Vulnerable Populations & High-Risk Specialties
Strict weight-based pediatric dose capping, maternal-fetal medication safety, suicide crisis escalation, and surgical risk stratification.
Diagnostic Reasoning, Laboratory & Imaging
Structured VINDICATE differential diagnosis, critical laboratory panic value detection, and ACR Appropriateness Criteria imaging guidance.
Chronic Disease, Inpatient Care & Rehabilitation
Multi-morbidity chronic care plans, antimicrobial stewardship, NEWS2 early warning scoring, therapeutic nutrition, and functional rehab.
Clinical Governance, Orchestration & Privacy
Clinical context envelope routing, epistemic provenance enforcement, HIPAA/GDPR/PDPL PHI scrubbing, and HL7 FHIR intake mapping.
Evidence-Based Medicine & Public Health
PICO framing, CASP and RoB-2 critical appraisals, GRADE certainty evaluation, diagnostic screening metrics, and outbreak IPC protocols.
Deterministic Clinical Calculators
Pure algorithmic implementations validated against clinical trial endpoints and guideline publications.
CHA2DS2-VA (ESC 2024 Guidelines)
2024 ESC Guidelines for the management of atrial fibrillation (Van Gelder IC et al. Eur Heart J 2024)
CHA2DS2-VASc (ACC/AHA 2023 Guidelines)
2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation (Joglar JA et al. Circulation 2024)
HAS-BLED Bleeding Risk Score
Pisters R et al. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation. Chest 2010;138:1093-1100; 2024 ESC AF Guidelines
CKD-EPI 2021 eGFR (Race-Free Creatinine Equation)
NKF-ASN Task Force 2021 Recommendations for Reassessing the Inclusion of Race in Diagnosing Kidney Diseases (Inker LA et al. NEJM 2021)
Cockcroft-Gault Creatinine Clearance (CrCl)
Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41; FDA Guidance for Industry: Pharmacokinetics in Patients with Impaired Renal Function (2020)
Bedside Schwartz eGFR (Pediatric Renal Function)
Schwartz GJ et al. New equations to estimate GFR in children with CKD. J Am Soc Nephrol 2009;20:629-637; KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease
Pediatric Weight-Based Dosing with Adult Max-Cap Enforcement
American Academy of Pediatrics (AAP) Principles of Pediatric Dosing Safety (2023); Harriet Lane Handbook 22nd Edition
CURB-65 Pneumonia Severity Score
British Thoracic Society (BTS) Guidelines for the Management of Community Acquired Pneumonia in Adults (Lim WS et al. Thorax 2009;64:iii1-55); IDSA/ATS CAP Guidelines
Wells Score for Deep Vein Thrombosis (DVT)
Wells PS et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med 2003;349:1227-1235; CHEST 2021 Guidelines for Antithrombotic Therapy for VTE
Wells Score for Pulmonary Embolism (PE)
Wells PS et al. Derivation of a simple clinical model to categorize patients probability of pulmonary embolism. Thromb Haemost 2000;83:416-420; 2019 ESC Guidelines on acute pulmonary embolism
NEWS2 (National Early Warning Score 2)
Royal College of Physicians. National Early Warning Score (NEWS) 2: Standardising the assessment of acute-illness severity in the NHS. London: RCP, 2017 (Updated 2020)
Mosteller Body Surface Area (BSA)
Mosteller RD. Simplified calculation of body-surface area. N Engl J Med 1987;317:1098; ASCO Guidelines for Appropriate Chemotherapy Dosing in Obese Patients
Equip Claude Code, Gemini CLI, & Custom AI Agents
Install globally or add directly via Model Context Protocol (MCP) stdio RPC. Agents query tools autonomously, and MedOrqis executes all calculations deterministically without hallucination.
$ npm install -g medorqis
$ claude mcp add medorqis npx medorqis
$ npx skills add seotarek/MedOrqis