Class C (IEC 62304 / MDR) Tier 3 v2.1.0

pharmacology-dosing-interactions

Pharmacology, Polypharmacy & Renal Dosing

Intended Clinical Purpose

Calculates precise drug dosages based on weight and renal function (eGFR/CrCl), and intercepts contraindicated drug combinations.

Prohibited Clinical Uses & Gating Boundary

Calculating chemotherapy or NTI dosing without serum drug levels and renal/hepatic markers

Mandatory Input Parameters

drug_inn patient_demographics renal_function

Deterministic Dependencies

core.clinical_calculators core.context_validator core.safety_guardrails

Clinical Review Status: REFERENCE_SEED_REQUIRES_CLINICAL_SIGN_OFF

Claude Code & MCP Configuration

Add to Claude Code via MCP stdio:

$ claude mcp add pharmacology-dosing-interactions npx medorqis --skill=pharmacology-dosing-interactions

Skills CLI Execution

Dispatch directly to agent workspace:

$ npx skills run seotarek/MedOrqis/pharmacology-dosing-interactions

SKILL.md & Manifest Specification YAML Frontmatter

---
name: pharmacology-dosing-interactions
description: >-
  High-risk pharmacology, dosing, and drug interaction engine. Enforces strict renal and hepatic dose adjustments, verifies Narrow Therapeutic Index (NTI) drug levels, and blocks lethal drug-drug interactions.
allowed-tools: bash
license: Apache-2.0
compatibility: Linux, macOS, Windows (Python 3.10+, MCP stdio, Claude Code, Gemini CLI, Ope...