Interactive Clinical Workbench
MedOrqis v2.1.1 Kernel
Clinical Playground
Test real clinical scenarios, run deterministic mathematical engines, and inspect step-by-step mathematical derivations without token hallucination.
Select Patient Scenario:
Cardiology & Nephrology
Elderly Diabetic Patient with Atrial Fibrillation & CKD
3 Calculators
Pediatrics & Infectious Diseases
Pediatric Acute Otitis Media Weight-Dose Capping
2 Calculators
Orthopedics & Vascular Surgery
Postoperative Knee Arthroplasty with Unilateral Calf Swelling
2 Calculators
Emergency Medicine & Pulmonology
Emergency Room Community-Acquired Pneumonia Assessment
2 Calculators
Cardiology & Health Policy
Cardiology Guidelines Divergence: ESC 2024 vs ACC/AHA 2023
2 Calculators
Cardiology & Nephrology
Elderly Diabetic Patient with Atrial Fibrillation & CKD
72-year-old male presenting with palpitation and fatigue. Medical history includes hypertension, type 2 diabetes mellitus, and a remote TIA 3 years ago. Baseline serum creatinine is 1.4 mg/dL, weight 78 kg, height 175 cm.
Recommended:
Active Calculator
2021
CKD-EPI 2021 eGFR (Race-Free Creatinine Equation)
INTERMEDIATE RISK
NKF-ASN Task Force 2021 Recommendations for Reassessing the Inclusion of Race in Diagnosing Kidney Diseases (Inker LA et al. NEJM 2021) (2021)
CKD-EPI 2021 eGFR (Race-Free Creatinine Equation)
Applicable Population: Adults (>= 18 years), race-neutral
Calculated Score:
53.4
mL/min/1.73m²
Clinical Interpretation
G3a: Mild-to-moderately decreased (45 - 59 mL/min/1.73m²)
Guideline-Directed Recommendation
Stage 3a CKD. Evaluate albuminuria, adjust renally eliminated drugs, monitor twice yearly.
Clinical Alerts & Safety Warnings
- Equation assumes steady-state serum creatinine. In acute kidney injury (AKI), eGFR may substantially overestimate actual GFR.
- For drug dosing adjustments (FDA labels), also compute Cockcroft-Gault CrCl.
Deterministic Execution Trace
Zero-Token Arithmetic
Mathematical Formula
\text{eGFR} = 142 \times \min\left(\frac{S_{cr}}{\kappa}, 1\right)^\alpha \times \max\left(\frac{S_{cr}}{\kappa}, 1\right)^{-1.200} \times 0.9938^{\text{Age}} \times [1.012 \text{ if female}]
Step-by-Step Formula Progression:
1
Gender coefficient: kappa = 0.9, alpha = -0.302, female factor = 1
2
min(Scr/kappa, 1)^alpha = (1)^-0.302 = 1
3
max(Scr/kappa, 1)^-1.200 = (1.5556)^-1.2 = 0.5885
4
Age decay: 0.9938^72 = 0.639
5
Calculated eGFR: 53.4 mL/min/1.73m²
Invariant Input Payload:
{
"age_years": 72,
"biological_sex": "MALE",
"hx_heart_failure": false,
"hx_hypertension": true,
"hx_diabetes": true,
"hx_stroke_tia_thromboembolism": true,
"hx_vascular_disease": false,
"serum_creatinine_mg_dl": 1.4,
"weight_kg": 78,
"height_cm": 175,
"uncontrolled_hypertension_sbp_gt_160": false,
"abnormal_renal_function": false,
"abnormal_liver_function": false,
"stroke_history": true,
"prior_major_bleeding_or_predisposition": false,
"labile_inr": false,
"medications_antiplatelets_nsaids": false,
"alcohol_excess": false
}