Interactive Clinical Workbench
MedOrqis v2.1.1 Kernel
Clinical Playground
Test real clinical scenarios, run deterministic mathematical engines, and inspect step-by-step mathematical derivations without token hallucination.
Select Patient Scenario:
Cardiology & Nephrology
Elderly Diabetic Patient with Atrial Fibrillation & CKD
3 Calculators
Pediatrics & Infectious Diseases
Pediatric Acute Otitis Media Weight-Dose Capping
2 Calculators
Orthopedics & Vascular Surgery
Postoperative Knee Arthroplasty with Unilateral Calf Swelling
2 Calculators
Emergency Medicine & Pulmonology
Emergency Room Community-Acquired Pneumonia Assessment
2 Calculators
Cardiology & Health Policy
Cardiology Guidelines Divergence: ESC 2024 vs ACC/AHA 2023
2 Calculators
Cardiology & Nephrology
Elderly Diabetic Patient with Atrial Fibrillation & CKD
72-year-old male presenting with palpitation and fatigue. Medical history includes hypertension, type 2 diabetes mellitus, and a remote TIA 3 years ago. Baseline serum creatinine is 1.4 mg/dL, weight 78 kg, height 175 cm.
Recommended:
Active Calculator
1976
Cockcroft-Gault Creatinine Clearance (CrCl)
INTERMEDIATE RISK
Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41; FDA Guidance for Industry: Pharmacokinetics in Patients with Impaired Renal Function (2020) (1976)
Cockcroft-Gault Creatinine Clearance (CrCl)
Applicable Population: Adults (>= 18 years) for pharmacokinetic drug dosage adjustment
Calculated Score:
52.6
mL/min
Clinical Interpretation
Moderate Renal Impairment (30 - 59 mL/min)
Guideline-Directed Recommendation
Mandatory dose reductions for DOACs (e.g. Apixaban, Rivaroxaban), enoxaparin, and renally excreted antibiotics.
Clinical Alerts & Safety Warnings
- Cockcroft-Gault is the reference method mandated by FDA and EMA package inserts for renal drug dosing adjustments.
- Do not round serum creatinine up to 1.0 mg/dL in elderly patients without clinical justification as it systematically underestimates renal clearance.
Deterministic Execution Trace
Zero-Token Arithmetic
Mathematical Formula
\text{CrCl} = \frac{(140 - \text{Age}) \times \text{Weight (kg)}}{72 \times S_{cr} \text{ (mg/dL)}} \times [0.85 \text{ if female}]
Step-by-Step Formula Progression:
1
Ideal Body Weight (IBW, Devine formula): 70.5 kg
2
Selected dosing weight: 78 kg (Actual Body Weight (within normal range of IBW))
3
Calculated CrCl: 52.6 mL/min
Invariant Input Payload:
{
"age_years": 72,
"biological_sex": "MALE",
"hx_heart_failure": false,
"hx_hypertension": true,
"hx_diabetes": true,
"hx_stroke_tia_thromboembolism": true,
"hx_vascular_disease": false,
"serum_creatinine_mg_dl": 1.4,
"weight_kg": 78,
"height_cm": 175,
"uncontrolled_hypertension_sbp_gt_160": false,
"abnormal_renal_function": false,
"abnormal_liver_function": false,
"stroke_history": true,
"prior_major_bleeding_or_predisposition": false,
"labile_inr": false,
"medications_antiplatelets_nsaids": false,
"alcohol_excess": false
}